MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is a 16-amino acid peptide encoded within the mitochondrial genome, and one of a small class of mitochondria-derived peptides drawing significant attention in metabolic research. For a deeper scientific overview of the compound's mechanism, see our MOTS-c research overview. For researchers in Malaysia studying mitochondrial signalling, insulin sensitivity, or exercise physiology, MOTS-c is now accessible locally through Concept Peptides without the complications of international ordering.
Note: MOTS-c supplied by Concept Peptides is a research-grade compound intended strictly for laboratory and preclinical research purposes. It is not for human consumption. Researchers requiring MOTS-c for clinical or licensed medical use should approach their institutional pharmacy or a licensed pharmaceutical distributor.
What Makes MOTS-c Different
Mitochondria-Derived Origin
Unlike most research peptides, which are encoded in the nuclear genome, MOTS-c is produced from a sequence within the mitochondrial 12S ribosomal RNA gene. This challenged the long-held assumption that the mitochondrial genome produces only components of the oxidative phosphorylation machinery, and positions MOTS-c as an endocrine-like signal linking mitochondrial status to whole-body metabolic regulation.
Insulin Sensitivity and AMPK Activation
MOTS-c exerts much of its metabolic effect through activation of AMP-activated protein kinase (AMPK), the master metabolic sensor. In research models, this drives enhanced glucose uptake, increased fatty acid oxidation, reduced lipogenesis, and improved insulin sensitivity — with MOTS-c administration shown to protect against high-fat diet-induced metabolic dysfunction in rodent studies.
Exercise Mimetic Properties
A distinctive feature of MOTS-c research is its apparent ability to recapitulate aspects of the exercise response at a molecular level — circulating MOTS-c rises with physical activity, and exogenous administration has been shown to improve exercise capacity and endurance in aged research models, making it a compound of interest in both metabolic and longevity research. For another mitochondria-focused compound with a distinct, membrane-level mechanism, see our article on SS-31.
How to Buy MOTS-c in Malaysia
Local vs Overseas Sourcing
MOTS-c research peptide sourced from overseas typically arrives in 3–5 weeks and involves customs risk. As a Malaysia-based supplier, Concept Peptides ships MOTS-c domestically with 1–3 business day delivery and no import complications. Every product is accompanied by a third-party Certificate of Analysis confirming sequence accuracy and purity. Researchers comparing sourcing logistics across our metabolic research range may also find our Tirzepatide Malaysia buying guide useful.
What Format Is It Supplied In?
Concept Peptides supplies MOTS-c as a lyophilised (freeze-dried) powder in sealed research vials, available in a 40mg size. Lyophilisation preserves stability and extends shelf life prior to reconstitution. It is reconstituted with BAC Water prior to use. A free BAC Water vial is included with every MOTS-c order.
Purity Verification
Every product is independently tested by a third-party laboratory and a Certificate of Analysis (COA) is available upon request, confirming the amino acid sequence, molecular weight, and purity percentage by HPLC.
Frequently Asked Questions
What is MOTS-c used for in research?
MOTS-c is used in preclinical and research settings to study mitochondrial signalling and its downstream effects on insulin sensitivity, AMPK activation, fat oxidation, and exercise capacity — positioning it as a compound of interest in metabolic and longevity research.
Where can I buy MOTS-c in Malaysia?
Research-grade MOTS-c is not sold in pharmacies or retail stores in Malaysia. Concept Peptides is a Malaysia-based supplier stocking MOTS-c in lyophilised research-grade format, with local payment methods and domestic shipping throughout Malaysia — order via WhatsApp or through the product page directly.
Is MOTS-c available in Malaysia?
Yes — Concept Peptides stocks MOTS-c in lyophilised research-grade format, available for order with local payment methods and domestic shipping throughout Malaysia, strictly for research and laboratory use.
How should it be stored after arrival?
Lyophilised MOTS-c should be stored at -20°C for long-term stability. If the vial will be used within 4–6 weeks, storage at 2–8°C is acceptable. Once reconstituted with BAC water, store the solution at 2–8°C and use within 28 days. Avoid repeated freeze-thaw cycles of the reconstituted preparation.
References
- Lee C, Zeng J, Drew BG, et al. "The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance." Cell Metabolism. 2015;21(3):443–454.
- Kim KH, Son JM, Benayoun BA, Lee C. "The mitochondrial-encoded peptide MOTS-c translocates to the nucleus to regulate nuclear gene expression in response to metabolic stress." Cell Metabolism. 2018;28(3):516–524.